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Open Access Short report

Outcome of match related allogeneic stem cell transplantation procedures performed from 2004 till 2011

Natasha Ali13*, Salman Naseem Adil1, Mohammad Usman Shaikh1, Munira Moosajee2 and Nehal Masood2

Author Affiliations

1 FCPS Haematology, Department of Pathology and Microbiology, The Aga Khan University and Hospital, Karachi, Pakistan

2 Department of Medicine, The Aga Khan University and Hospital, Karachi, Pakistan

3 Department of Pathology and Microbiology, The Aga Khan University Hospital, P.O Box 3500, Stadium Road, Karachi, 74800, Pakistan

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Experimental Hematology & Oncology 2012, 1:13  doi:10.1186/2162-3619-1-13

Published: 18 May 2012

Abstract

We present our initial experience of allogeneic stem cell transplant procedure performed between April 2004 and August 2011 for various haematological disorders. All patients with non-malignant and malignant haematological disorders with HLA matched donors were selected after pre-transplant workup. Ninety seven patients underwent the procedure. Most common indications for transplant were aplastic anaemia in n = 34 (35%), followed by β-Thalassemia major in n = 21 (21.6%) and chronic myeloid leukemia in n = 11 patients (11.3%). Primary graft failure present was present in 2.06%. Incidence of graft versus host disease (GvHD) in our patients was 34%. After median follow-up of five years the overall survival was 71.3% with a mean survival time of 51.2 ± 3.3 months.

Keywords:
Outcome; Allogeneic transplant; Overall survival; Allogeneic transplant; GvHD; Overall survival