Email updates

Keep up to date with the latest news and content from Experimental Hematology and Oncology and BioMed Central.

Open Access Case report

“T-cell prolymphocytic leukemia (T-PLL), a heterogeneous disease exemplified by two cases and the important role of cytogenetics: a multidisciplinary approach”

Carlos A Tirado1*, Phillip Starshak1, Paul Delgado2 and Nagesh Rao1

Author Affiliations

1 Department of Pathology & Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA, 90095, USA

2 Department of Ecology and Evolutionary Biology, UCLA, Los Angeles, CA, 90095, USA

For all author emails, please log on.

Experimental Hematology & Oncology 2012, 1:21  doi:10.1186/2162-3619-1-21

Published: 20 August 2012

Abstract

T-cell prolymphocytic leukemia (T-PLL) is a rare form of leukemia composed of mature T-cells that usually presents in older people with a median age of 65. Most cases of T-PLL will harbor chromosomal abnormalities involving 14q11.2 (TCR alpha/delta), 14q32 (TCL1) or Xq28 (MTCP-1), abnormalities of chromosome 8, 12p and deletions of the long arm of chromosomes 5, 6, 11 and 13. Cytogenetics, FISH, comparative genomic hybridization (CGH) , SNP arrays with high resolution analysis have provided more precisely frequent submicroscopic gene and genomic lesions as well as breakpoints involved in the pathogenesis of this disease. One of the cornerstones to diagnose T-PLL are cytogenetic analysis. Here we summarize the current cytogenetic findings and we also describe two distinct cases of T-PLL where cytogenetics, FISH , morphologic analysis and flow cytometry helped to diagnose them accurately.

Keywords:
T-PLL; Cytogenetics; FISH