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Open Access Case report

A Japanese case of chronic lymphocytic leukemia with t (1;6)

Kayo Harada1, Kazuhiko Ikeda1*, Hayato Matsumoto1, Miki Furukawa1, Hiroshi Takahashi1, Hiroshi Ohkawara1, Hideyoshi Noji1, Kazuhiro Tasaki2, Masafumi Abe2, Kazuei Ogawa1 and Yasuchika Takeishi1

Author Affiliations

1 Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikariga-oka, Fukushima, Fukushima, 960-1295, Japan

2 Department of Pathology and Diagnostic Pathology, Fukushima Medical University, Fukushima, Japan

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Experimental Hematology & Oncology 2012, 1:28  doi:10.1186/2162-3619-1-28

Published: 12 September 2012

Abstract

Chronic lymphocytic leukemia (CLL) rarely exhibits an aggressive clinical course and its patients often have chromosomal deletions or additions. Furthermore, reciprocal translocations are barely observed in CLL. There have only been a few reports of CLL with t(1;6), and here we report the first Asian case of CLL with reciprocal translocation t(1;6). Since our case and previously reported CLL patients with t(1;6) consistently showed aggressive clinical course, t(1;6) may define a distinct type of CLL.

Keywords:
CLL; T(1;6); Aggressive clinical course