A Japanese case of chronic lymphocytic leukemia with t (1;6)
1 Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikariga-oka, Fukushima, Fukushima, 960-1295, Japan
2 Department of Pathology and Diagnostic Pathology, Fukushima Medical University, Fukushima, Japan
Experimental Hematology & Oncology 2012, 1:28 doi:10.1186/2162-3619-1-28Published: 12 September 2012
Chronic lymphocytic leukemia (CLL) rarely exhibits an aggressive clinical course and its patients often have chromosomal deletions or additions. Furthermore, reciprocal translocations are barely observed in CLL. There have only been a few reports of CLL with t(1;6), and here we report the first Asian case of CLL with reciprocal translocation t(1;6). Since our case and previously reported CLL patients with t(1;6) consistently showed aggressive clinical course, t(1;6) may define a distinct type of CLL.