Case report
Intravascular CNS lymphoma: Successful therapy using high-dose methotrexate-based polychemotherapy
1 Division of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany
2 Department of Radiology, University of Bonn Medical Center, Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany
3 Department of Neuropathology, University of Bonn Medical Center, Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany
4 Department of Oncology, University of Bonn Medical Center, Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany
5 Stem Cell Pathologies, Institute of Reconstructive Neurobiology, University of Bonn Medical Center, Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany
Experimental Hematology & Oncology 2012, 1:37 doi:10.1186/2162-3619-1-37
Published: 5 December 2012Abstract
Intravascular diffuse large B-cell lymphoma limited to the CNS (cIVL) is a very rare malignant disorder characterized by a selective accumulation of neoplastic lymphocytes (usually B cells) within the lumen of CNS blood vessels but not in the brain parenchyma. In the past, treatment of cIVL with anthracycline-based regimens was unsatisfactory with very short survival times. In the case of cIVL presented here, high-dose methotrexate-based polychemotherapy according to the Bonn protocol plus rituximab therapy was successful and led to a complete clinical and MRI remission which is ongoing 29 months after diagnosis.
